Endocrine Abstracts

Background: Joint British Diabetes Societies (JBDS) have developed guidelines for the treatment and management of diabetic ketoacidosis (DKA) in adults in the United Kingdom (UK). Multiple single center audits are known to assess compliance to guidelines. However, unified data on DKA management across multiple centers is unknown.Aims: To study the precipitating factors and assess for differences in DKA management across UK hospitals.<p class="abstext...

Background: The appropriate and timely management of diabetes-related ketoacidosis (DKA) has important implications for patient outcomes. Despite the availability of national management guidelines to promote standardised care, we do not know if there are differences in DKA outcomes and complications between hospitals.Aim: To assess for differences in DKA outcomes and treatment complications between hospitals.Methods: This retrospec...

Non-functioning pituitary macroadenomas (NFPAs) are commonly associated with headaches, visual deficits and hypopituitarism. Urgent transsphenoidal surgery (TSS) should be considered for all patients presenting with visual compromise. We evaluated outcomes in 65 patients with NFPAs undergoing TSS in our unit. Patients who had undergone previous pituitary surgery or prior radiotherapy were excluded from this evaluation, as were those with classical pituitary apoplexy and predom...

Background: Preexisting chronic autoimmune thyroiditis is the only known risk factor for thyroid lymphomas, a rare variant of thyroid cancer. Here, we describe a male patient with previously undiagnosed Hashimoto’s thyroiditis who presented with severe airway compromise due to a thyroid lymphoma.Case report: 60 y/o, former smoker, presented with 2 month neck fullness and dyspnea that awakened him throughout the night due to malpositioning of his nec...

Hypopituitarism is a potential complication of trans-sphenoidal adenomectomy (TSA). Prediction of pituitary function (PF) recovery would inform hormonal replacement strategies. However, the frequency of re-testing of PF is variable across centres. The aim of this study was to determine rates, time and predictors of 6-weeks (6 w) recovery of hypothalamo-pituitary adrenal (HPA) and gonadal function after TSA.Methods: We performed a single-centre, retrospec...

Introduction: Familial Partial Lipodystrophies (FPLD) are rare genetic disorders characterized by marked loss of subcutaneous fat from the extremities with variable fat loss from the face and trunk. Patients with FPLD develop metabolic abnormalities including hypertriglyceridemia, insulin resistance, and diabetes mellitus, which are difficult to manage with conventional therapies including fibrates, statins and insulin. The BROADEN study evaluated the efficacy a...

Introduction: Familial Partial Lipodystrophy (FPLD) is a rare genetic disorder characterized by marked loss of subcutaneous adipose tissue from the extremities and is associated with a variety of metabolic abnormalities. While phenotypic elements of the disorder can vary across genotypes, symptomatic presentation, disease severity, and onset can also vary among individuals with the same disease-causing variant, or even among family members. Due to this variabili...

Purpose: Although quality of life (QoL) is improved in patients with acromegaly after disease control, QoL correlates only weakly with traditional biomarkers. Our objective is to investigate a potential relation between the new serum biomarker soluble Klotho (sKlotho), GH and insulin-like growth factor 1 (IGF-1) levels and QoL.Methods: In this prospective cohort study, we investigated 54 acromegaly patients biochemically well-controlled on combination tr...

Habitual post-prandial absorption of saturated fatty acids (SFAs) increases systemic atherogenic lipoproteins and a pro-inflammatory response, a condition exacerbated by obesity, insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Also, gut derived bacteria (endotoxin) is absorbed coupled to damaging lipoproteins as it crosses the mucosa, which could directly impact on adipose tissue, as our previous studies suggest. The current studies addressed whether a SFA rich me...

Introduction: Various imaging modalities are used in the preoperative localization of insulinoma. CT is the modality that is in widespread use. Endoscopic ultrasound (EUS) allows the transducer to be placed in close proximity to the pancreas, thereby yielding images of higher quality, leading to accurate localization. An accurate preoperative localization results in a minimal invasive surgery and less occurrence of residual tumors, translating into a better clinical outcome. O...